late 14c., farmacie, "a medicine that rids the body of an excess of humors (except blood);" also "treatment with medicine; theory of treatment with medicine," from Old French farmacie "a purgative" (13c.) and directly from Medieval Latin pharmacia, from Greek pharmakeia "a healing or harmful medicine, a healing or poisonous herb; a drug, poisonous potion; magic (potion), dye, raw material for physical or chemical processing."

This is from pharmakeus (fem. pharmakis) "a preparer of drugs, a poisoner, a sorcerer" from pharmakon "a drug, a poison, philter, charm, spell, enchantment." Beekes writes that the original meaning cannot be clearly established, and "The word is clearly Pre-Greek." The ph- was restored 16c. in French, 17c. in English (see ph).